PUBLICATIONS LES PLUS RÉCENTES
PUBLICATIONS LES PLUS REPRESENTATIVES
PRINCIPAUX OUVRAGES
PRINCIPAUX ARTICLES
DISCOURS LES PLUS REPRESENTATIFS
PUBLICATIONS LES PLUS RÉCENTES
2012
Giustiniani J., Sineus M., Sardin E., Dounane O., Panchal M., Sazdovitch V., DuyckaertsC., Chambraud B.and Baulieu E.E.
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer’s disease and FTDP-17.
Journal of Alzheimer Disease in press, 2012.
Bianchi M. and Baulieu E.E.
3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders.
Proc Natl Acad Sci USA doi/10.1073/pnas.1121485109, 2012.
Dumas de La Roque E., Savineau J.P., Metivier A.C., Billes M.A., Kreamer J.P., Doutreleau S., Jougon J., Marthan R., Moore N., Fayon M., Baulieu E.E., Dromer C.
Dehydroepiandrosterone (DHEA) improves Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease (COPD): a Pilot Study. Annales d’Endocrinologie in press, 2012.
2011
Duchossoy Y., David S., Baulieu E.E., Robel P.
Treatment of experimental spinal cord injury with 3b-methoxy-pregnenolone. Brain Research 1403:57-66, 2011.
Rakotomamonjy J., Levenes C., Baulieu E.E., Schumacher M., and Ghoumari A.
Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons. The FASEB Journal doi: 10.1096/fj.11-183384, 2011.
Ladurelle N., Gabriel C., Viggiano A., Mocaër E., Baulieu E.E., Bianchi M.
Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology doi: 10.1007/s00213-011-2597-5, 2011.
2010
Chambraud B., Sardin E., Giustiniani J., Dounane O., Schumacher M., Goedert M. and Baulieu E.E.
A role for FKBP52 in Tau protein function. Proc Natl Acad Sci USA 107: 2658-2663, 2010.
2009
Baulieu E.E.
Gérontologie préventive : un rôle pour les neurostéroïdes ? in : Gérontologie préventive, Eléments de prévention du vieillissement pathologique, 2e édition, C. Trivalle, ed. (Elsevier Masson, Abrégés de Médecine, Issy-les-Mx), 8:91-96, 2009.
Sanchez P.E., Fares R.P., Risso J.J., Bonnet C., Bouvard S., Le-Cavorsin M., Georges B., Moulin C., Belmeguenai A., Bodennec J., Morales A., Pequignot J.M., Baulieu E.E., Levine R.A., and Bezin L.
Optimal neuroprotection by erythropoietin requires elevated expression ot its receptor in neurons. Proc Natl Acad Sci USA 106:9848-9853, 2009.
Baulieu E.E.
La dépendance et les progrès de la recherche biomédicale. Risques 78:34-35, 2009.
El-Etr M., Vukusic S., Confavreux C., Baulieu E.E., Schumacher M.
Hormones sexuelles et sclérose en plaques. Médecine & Longévité 1:3-11, 2009.
Liere P., Pianos A., Eychenne B., Cambourg A., Bodin K., Griffith W., Schumacher M., Baulieu E.E., and Sjövall J. Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key. Journal of Lipid Research 50:2430-2444, 2009.
2008
Dessouroux A., Akwa Y., Baulieu E.E.
DHEA decreases HIF-1a accumulation under hypoxia in human pulmonary artery cells: Potential role in the treatment of pulmonary arterial hypertension. J. Steroid Biochem. Mol. Biol. 109:81-89, 2008.
Baulieu E.E., Le Bouc Y., Souberbielle J.C. et Vermeulen A.
Hormones, longévité et vieillissement humain. in : Hormones, santé publique et environnement.. E. Milgrom, E.E. Baulieu eds (EDP Sciences, Paris). Rapport sur la Science et la Technologie n° 28, 4:151-192, 2008.
Schumacher M., Liere P., Akwa Y., Rajkowski K., Griffiths W., Bodin K., Sjövall J., Baulieu E.E.
Pregnenolone sulfate in the brain: a controversial neurosteroid. Neurochemistry International 52:522-540, 2008.
Girard C., Liu S., Cadepond F., Adams D., Lacroix C., Verleye M., Gillardin J.M., Baulieu E.E., Schumacher M., and Schweizer-Groyer G.
Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci USA 105:20505-20510, 2008.
2007
Broué F., Liere P., Kenyon C. and Baulieu E.E.
A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Ce1l 6:87-94, 2007.
Baulieu E.E.
Entretien avec le professeur E.E. Baulieu (propos recueillis en avril 2002 et révisés en octobre 2006). in : Les Dialogues stratégiques. V. Anger ed (Des Idées & des Hommes, Paris), I 83-187, 2007.
Chambraud B., Belabes H., Fontaine-Lenoir V., Fellous A. and Baulieu E.E.
The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. The FASEB Journal 21:2787-2797, 2007.
Schumacher M., Guennoun R., Ghoumari A., Massaad C., Robert F., EI-Etr M., Akwa Y., Rajkowski K., and Baulieu E.E.
Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system. Endocrine Reviews 28:387-439, 2007.
PUBLICATIONS LES PLUS REPRESENTATIVES
BAULIEU, E.-E., LASNITZKI, I., ROBEL, P.
Metabolism of testosterone and action of metabolites on prostate glands grown in organ culture
Nature (1968) 219, 1155-1156
BAULIEU, E.-E., GODEAU, J.F., SCHRODERET, M., SCHORDERET-SLATKINE, S.
Steroid induced meiotic division in Xenopus laevis oocytes: surfaces and calcium.
Nature (1978) 275, 593-598
FINIDORI-LEPICARD, J., SCHORDERET-SLATKINE, S., HANOUNE, J., BAULIEU, E.-E.
Steroid hormone as regulatory agent of adenylate cyclase. Inhibition by progesterone of the membrane bound enzyme in Xenopus laevis oocytes
Nature (1981) 292, 255-256
CORPECHOT, C., ROBEL, P., AXELSON, M., SJÖVALL, J., BAULIEU, E.-E.
Characterization and measurement of dehydroepiandrosterone sulfate in the rat brain
Proc. Natl. Acad. Sci., USA (1981) 78, 4704-4707
W.HERRMANN, R.WYSS, A.RIONDEL, D.PHILIBERT, G.TEUSCH, E.SAKAIZ, E-E. BAULIEU
Effet d’un Stéroide anti-progestéro
Compte-rendu des séances de l’Académie des Sciences. (1982), 294, P.933-938
JOAB, I., RADANYI, C., RENOIR, J.M., BUCHOU, T., CATELLI, M.G., BINART, N., MESTER, J., BAULIEU; E.-E.
Immunological evidence for a common non hormone-binding component in » non-transformed » chick oviduct receptors of four steroid hormones
Nature (1984) 308, 850-853
BAULIEU, E.-E.
Contragestion and other applications of RU486, an antiprogesterone at the receptor
Science (1989) 245, 1351-1357
LEBEAU, M.C., MASSOL, N., HERICK, J., FABER, L.E., RENOIR, J.M, RADANYI, C., BAULIEU, E.-E.
P59, an hsp90 binding protein; cloning and sequencing of its cDNA. Preparation of a peptide-directed polyclonal antibody.
J. Biol. Chem. (1992) 267, 4281-4284
PEYRON, R., AUBENY, E., TARGOSZ, V., SILVESTRE, L., RENAULT, M., ELKIK, F., LECLERC, P., ULMANN, A., BAULIEU, E.-E.
Early termination of pregnancy with mifepristone (RU486) and the orally active prostaglandin Misoprostol.
New Engl. J. Med.(1993) 328, 1509-1513
RADANYI, C., CHAMBRAUD, B., BAULIEU, E.-E.
The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetrotricopeptide repeat domain.
Proc. Natl. Acad. Sci. USA (1994) 91, 11197-11201
KOENIG, H.L., SCHUMACHER, M., FERZAZ, B., DO THI, A.N., RESSOUCHES, A., GUENNOUN, R., JUNG-TESTAS, I., ROBEL, P., AKWA, Y., BAULIEU, E.-E.
Progesterone synthesis and myelin formation by Schwann cells.
Science (1995) 268, 1500-1503
BERR, C., LAFONT, S., DEBUIRE, B., DARTIGUES, J.F., BAULIEU, E.-E.
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality. A French community-based study
Proc. Natl. Acad. Sci. USA (1996) 93, 13410-13415
CHAMBRAUD, B., RADANYI, C., CAMONIS, H., RAJKOWSKI, K., SCHUMACHER, M., BAULIEU, E.-E.
Immunophilins, Refsum disease and Lupus nephritis. The peroxisomal enzyme phytanoyl-coa a-hydroxylase is a new FKBP-associated-protein.
Proc. Natl. Acad. Sci. USA (1999) 96, 2104-2109
SCHUMACHER, M., AKWA, Y., GUENNOUN, R., ROBERT, F., LABOMBARDA, F., DESARNAUD, F., ROBEL, P., DE NICOLA, A.F., BAULIEU, E.-E.
Steroid synthesis and metabolism in the nervous system : Trophic and protective effects.
Journal of Neurocytology (2000) 29, 307-326
BERR, C., LAFONT, S., DEBUIRE, B., DARTIGUES, J.F., BAULIEU, E.-E.
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality. A French community-based study
Proc. Natl. Acad. Sci. USA (1996) 93, 13410-13415
THOMAS, G. , LEGRAIN,S., LAHLOU, N., ROGER., M., DEBUIRE, B., FAUCOUNAU, V., GIRARD, L., HERVY, M.P., LATOUR, F., LEAUD, M.C., MOKRANE, A., PITTI-FERRANDI, H., TRIVALLE, C., DE LACHARRIERE, O., NOUVEAU, S., RAKOTO-ARISON, B., SOUBERBIELLE, J.C., RAISON, J., LE BOUC, Y., RAYNAUD, A., GIRERD, X., FORETTE, F.
Dehydroepiandrosterone sulfate and aging : contribution of the DHEAge study to a social biomedical issue
Proc. Natl. Acad. Sci. USA (2000) 97, 4279-4284
AKWA Y., LADURELLE N., COVEY D.F., BAULIEU E.-E.
The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart : distinct mechanisms ?
Proc. Natl. Acad. Sci. USA (2001) 98, 14033-14037
MAZAT L., LAFONT S., BERR C., DEBUIRE B, TESSIER J.F., DARTIGUES J.F., BAULIEU E.-E.
Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects : Relationship to gender, subjective health, smoking habits and 10-year mortality
Proc. Natl. Acad. Sci. USA (2001) 98, 8145-8150
PRINCIPAUX OUVRAGES
BAULIEU E.-E., KELLY P. A.
Hormones : from molecules to diseases
Ed. Hermann (1990) 697 p.
BAULIEU E.-E.
Génération pilule
Ed. Odile Jacob (1990) 314 p.
BAULIEU E.-E.
The abortion Pill
Ed. Simon & Scuster (1991) et Century (1992)
BAULIEU E.-E., ROBEL P., SCHUMACHER M.
Neurosteroids : a new regulatory function in the nervous system
Ed. Humana Press (1999) 378 p.
BAULIEU É.-É., HÉRITIER F., LÉRIDON H.
Contraception, contrainte ou liberté ?
Ed. Odile Jacob (1999) 305 p.
BAULIEU E.-E.
Longévité, tous centenaires ?
Ed. Platyplus Press (2003) 125 p.
PRINCIPAUX ARTICLES
PLASSART-SCHIESS E. and BAULIEU E.E.
« New » modes of action of steroids : the case of neurosteroids In : Menopause, hormones and cancer, Proceedings of the 2nd International Symposium of the Portuguese Menopause Society, Neves-e-Castro M. and Wren
B.G. eds (Parthenon Publishing, London), chap. 1, 1-8, 2002.
BELANOFF J.K., ROTHSCHILD A.J., CASSIDY F., DEBATTISTA C., BAULIEU E.E., SCHOLD C., and SCHATZBERG A.F.
An open label trial of C-1073 (Mifepristone) for psychotic major depression
Biol Psychiatry, 52, 386-392, 2002.
WEILL-ENGERER S., DAVID J.P., SAZDOVITCH V., LIERE P., EYCHENNE B., PIANOS A., SCHUMACHER M., DELACOURTE A., BAULIEU E.E., and AKWA Y.
Neurosteroid quantification in human brain regions : comparison between Alzheimer’s and nondemented patients.
J. Clin. Endocrinol. Metab., 87, 5138-5143, 2002
BAULIEU E.E.
Andropause at the beginning of the new century : a few remarks on hormones and aging of men. In : Women’s Health and Menopause. New strategies-improved quality of life.
R.A. Lobo, P.G. Crosignani, R. Paoletti and F. Bruschi, eds (Fondazione Giovanni Lorenzini Milan, Kluwer Academic Publishers), 17, 7-21, 2002.
BENMESSAHEL Y., GUENNOUN R., CADEPOND F., BAULIEU E.E., SCHUMACHER M., GROYER G.
Expression of steroidogenic acute regulatory protein in cultured Schwann cells and its regulation by cAMP
Ann N Y Acad Sci, 973, 83-87, 2002.
CADEPOND F., MASSAAD C., TROUSSON A., GRENIER J., GROYER G., BAULIEU E.E., SCHUMACHER M.
Steroid receptors in various glial cell lines expression and functional studies.
Ann N Y Acad Sci, 973, 484-487, 2002.
BAULIEU E.E.
Androgens and aging men
Molecular and Cellular Endocrinology 198:41-49, 2002.
Weill-Engerer S., David J.P., Sazdovitch V., Liere P., Schumacher M., Delacourte A., Baulieu E.E., Akwa Y.
In vitro metabolism of dehydroepiandrosterone (DHEA) to 7a-hydroxy-DHEA and D5-androstene-3b-17b-diol in specific regions of the aging brain from Alzheimer’s and non-demented patients
Brain Research 969:117-125, 2003.
Krummrei U., Baulieu E.E. and Chambraud B.
The FKBP-associated protein FAP48 is an antioproliferative molecule and a player in T cell activation that increases IL2 synthesis
Proc Natl Acad Sci USA 100:2444-2449, 2003.
Percheron G., Hogrel J.Y., Denot-Ledunois S., Fayet G., Forette F., Baulieu E.E., Fardeau M., Marini J.F.
Effet of 1-year oral administration of Dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area
Arch Intern Med. 163:720-727, 2003.
Ghoumari A.M., Dusart I., El-Etr M., Tronche F., Sotelo C., Schumacher M., and Baulieu E.E.
Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum
Proc Natl Acad Sci USA 100:7953-7958, 2003.
Ibanez C., Guennoun R., Liere P., Eychenne B., Pianos A., El-Etr M., Baulieu E.E., and Schumacher M.
Developmental expression of genes involved in neurosteroidogenesis : 3b-hydroxysteroid dehydrogenase/D5-D4 isomerase in the rat brain
Endocrinology 144:2902-2911, 2003.
Bonnet S., Dumas de La Roque E., Bégueret H., Marthan R., Fayon M., Dos Santos P., Savineau J.P., and Baulieu E.E.
Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension
Proc Natl Acad Sci USA 100:9488-9493, 2003.
Ghoumari A.M., Ibanez C., El-Etr M., Leclerc P., Eychenne B., O’Malley B.W., Baulieu E.E. and Schumacher M.
Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum
J. Neurochem 86:848-859, 2003.
Akwa Y. and Baulieu E.E.
On the neurosteroid mechanisms of action and their clinical potentials. In : Neurosteroid effect in the central nervous system : the role of the GABAA
receptor, Smith S. ed. (CRC Press LLC, Boca Raton, USA), 17:359-372, 2003.
Ibanez C., Shields S.A., El-Etr M., Leonelli E., Magnaghi V., Li W.W., Sim F.J., Baulieu E.E., Melcangi R., Schumacher M., Franklin R.J.M.
Steroids and the reversal of age-associated changes in myelination and remyelination.
Progress in Neurobiology 71:49-56, 2003.
Schumacher M., Weill-Engerer S., Liere P., Robert F., Franklin R.J.M., Garcia-Segura L.M., Lambert J.J., Mayo W., Melcangi R.C., Parducz A., Suter U., Carelli C., Baulieu E.E., Akwa Y.
Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.
Progress in Neurobiology 71:3-29, 2003.
Massol N., Lebeau M.C., Schumacher M., and Baulieu E.E.
Promoter activity and gene structure of rabbit FKBP52
DNA and Cell Biology 22:505-511, 2003.
Ibanez C., Shields S.A., El-Etr M., Baulieu E.E., Schumacher M. and Franklin R.J.M.
Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats
Neuropathology and Applied Neurobiology 30:80-89, 2004
Ghoumari A.M., Baulieu E.E.
L’antistéroïde RU486 peut aussi protéger contre la mort neuronale
La Lettre du Neurologue VIII:75-76, mars 2004
Guennoun R., De Nicola A.F., Schumacher M. and Baulieu E.E.
Progesterone in the nervous system : an old player in new roles
In : Hormone replacement therapy and the brain. A.R. Genazzani ed. (International Menopause Society, The Parthenon Publishing Group), 57-71, 2004.
Schumacher M., Guennoun R., Robert F., Carelli C., Gago N., Ghoumari A., Gonzalez Deniselle M.C., Gonzales S.L., Ibanez C., Labombarda F., Coirini H., Baulieu E.E., De Nicola A.F.
Local synthesis and dual actions of progesterone in the nervous system : neuroprotection and myelination
Growth Hormone & IGF Research, 14:S18-S33, 2004.
Varet J., Vincent L., Akwa Y., Mirshahi P., Lahary A., Legrand E., Opolon P., Mishal Z., Baulieu E.E., Soria J., Soria C., Li H.
Dose-dependent effect of dehydroepiandrosterone, but not of its sulphate ester, on angiogenesis.
Eur. J. Pharmacol, 502:21-30, 2004.
Liere P., Pianos A., Eychenne B., Cambourg A., Liu S., Griffiths W., Schumacher M., Sjövall J. and Baulieu E.E.
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain.
J Lipid Res, 45:2287-2302, 2004.
Baulieu E.E., Robel P., Fellous A., Duchossoy Y., Fontaine-Lenoir V., David S.
Treating Alzheimer’s disease : new directions in drug discovery/development.
Journal of Molecular Neuroscience, 24:063-066, 2004.
Matsunaga M., Ukena K., Baulieu E.E., and Tsutsui K.
7a-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.
Proc Natl Acad Sci USA 101:17282-17287, 2004.
Schumacher M., Ghoumari A., Guennoun R., Labombarda F., Gonzalez S.L., Gonzalez Deniselle M.C., Massaad C., Grenier J., Rajkowski K.M., Robert F., Baulieu E.E., and De Nicola A.F.
Progestins and antiprogestins : mechanisms of action, neuroprotection and myelination.
in : Hormones and the Brain.. Kordon et al. eds (Springer-Verlag Berlin, Heidelberg), 111-154, 2005.
DISCOURS LES PLUS REPRESENTATIFS
BAULIEU E.E.
La recherche fondamentale et le devoir de communiquer
La Lettre de l’Académie des Sciences, 3, Editorial, 2002.
BAULIEU E.E.
Longévité et vieillissement : aspects scientifiques, médicaux et sociaux
La Lettre de l’Académie des Sciences, 3, 3-6, 2002.
Baulieu E.E.
a) La science est progrès – Allocution de prise de fonction du Professeur Etienne-Emile Baulieu, Président de l’Académie des sciences 2003-2004, 14 janvier 2003 [en ligne].
b) Science is Progress Address by Professor Etienne-Emile Baulieu, President of the Academy of Sciences 2003-2004, January 14, 2003 [on line].
Disponibles sur : http://www.academie-sciences.fr
Baulieu E.E.
a) Changements de la science, progrès pour l’homme ? Séance solennelle de rentrée des cinq Académies, 21 octobre 2003 [en ligne].
b) Scientific change, a step forward for mankind ? Official Opening Ceremony, October 21st, 2003 [on line].
Disponibles sur : http://www.academie-sciences.fr
Baulieu E.E.
Longévité et vieillissement : le rôle des hormones (Conférence du 15 mai 2003)
Bulletin de la Société des Amis des Universités de l’Académie de Strasbourg 57:47-58, 2003.
Baulieu E.E.
a) Discours prononcé par E.E. Baulieu le 27 novembre 2003, à l’Hôtel Matignon, lors de la remise de la Légion d’Honneur à sept membres de l’Académie des sciences par Jean-Pierre Raffarin, Premier Ministre [en ligne].
b) Speech by E.E. Baulieu, November 27, 2003, at the Hôtel Matignon at the invitation of Prime Minister Jean-Pierre Raffarin [on line].
Disponibles sur : http://www.academie-sciences.fr
Baulieu E.E., Robel P., Fellous A., Duchossoy Y., Fontaine-Lenoir V. et David S.
Des neurostéroïdes agissent directement au niveau des microtubules. Vers une nouvelle approche de la neuroprotection et du traitement de la maladie d’Alzheimer.
Communication présentée au colloque Nouvelles approches en neurosciences et maladies du système nerveux central, Paris (Académie des sciences), 10-12 mai 2004
Baulieu E.E.
Académie des sciences. Allocution du Président sortant Etienne-Emile Baulieu. Séance publique du 11 janvier 2005 [en ligne].
Allocution disponible sur : http://www.academie-sciences.fr
Baulieu E.E.
Le CIP, originalité d’une démarche, bilan de son fonctionnement 2004, la France et sa recherche.
in : Les Etats Généraux de la Recherche. D. Peschanski ed (Tallandier, Paris) XV:340-342, 2005.
Baulieu E.E., Brézin E.
La grande misère de la recherche en France.
in : le débat. Pierre Nora ed. (Gallimard) 134:92-104, 2005.
Baulieu E.E.
Le plaisir est excellent pour la santé.
in : Passionnément vieux. L. Delwasse, F. Delpech eds (Anne Carrère) 119-128, 2005.
Baulieu E.E.
Hormones, environnement et soi.
Communication présentée le 24 juin 2005 au Colloque : L’identité ? Soi et non soi, Institut de France, Paris.
Baulieu E.E.
La quête de la jouvence.
Sève 13:69-75,2007. Dossier: Le temps et la santé.
Baulieu E.E.
Entretien avec le professeur E.E. Baulieu (propos recueillis en avril 2002 et révisés en octobre 2006).
in : Les Dialogues stratégiques. V. Anger ed (Des Idées & des Hommes, Paris), I 83-187, 2007.
